GEO DataSets

(Submitter supplied) Glioblastoma (GBM) is an incurable brain tumor carrying a dismal prognosis, which displays considerable heterogeneity. We have recently identified recurrent H3F3A mutations affecting two critical positions of histone H3.3 (K27, G34) in one-third of pediatric GBM. Here we show that each of these H3F3A mutations defines an epigenetic subgroup of GBM with a distinct global methylation pattern, and are mutually exclusive with IDH1 mutation (characterizing a CpG-Island Methylator Phenotype (CIMP) subgroup). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4470

Platform:

GPL570

46 Samples

Download data: CEL

Analysis of glioblastoma (GBM) tumors from different regions of the brain from patients of various ages. Mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of GBM. Results provide insight into heterogeneity of GBM and oncogenic pathways leading to gliomagenesis.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 27 age, 7 disease state, 5 genotype/variation, 3 other, 13 tissue sets

Platform:

GPL570

Series:

GSE36245

46 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...

Organism:

Homo sapiens

602 DataSets

5670 Series

61 Related Platforms

175576 Samples

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