GEO DataSets

(Submitter supplied) The precise mechanism and effects of antibiotics in host gene expression and immunomodulation in MRSA infection is unknown. Using a well characterized Methicillin Resistant Staphylococcus aureus (MRSA) isolate USA300 in a murine model of infection, we determined that linezolid and vancomycin induced differential production of bacterial toxins and host cytokines, differences in host gene expression, and differences in immunomodulators during MRSA bloodstream infection. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5315

Platform:

GPL1261

35 Samples

Download data: CEL

Analysis of blood from A/J males injected with S. aureus USA300 then treated intravenously with linezolid (L) or vancomycin (V) for up to 24hr. L and V represent two different classes of antibiotics. Results provide insight into the molecular effects of each antibiotic on the host in MRSA sepsis.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 agent, 2 infection, 3 time sets

Platform:

GPL1261

Series:

GSE38531

35 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...

Organism:

Mus musculus

601 DataSets

4547 Series

40 Related Platforms

58950 Samples

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