GSM878949[Accession] - GEO DataSets

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Items: 3

Select item 2000359881.

The Mutational Landscape of Lethal Castrate Resistant Prostate Cancer

(Submitter supplied) Characterization of the prostate cancer transcriptome and genome has identified chromosomal rearrangements and copy number gains/losses, including ETS gene fusions, PTEN loss and androgen receptor (AR) amplification, that drive prostate cancer development and progression to lethal, metastatic castrate resistant prostate cancer (CRPC)1. As less is known about the role of mutations2-4, here we sequenced the exomes of 50 lethal, heavily-pretreated metastatic CRPCs obtained at rapid autopsy (including three different foci from the same patient) and 11 treatment naïve, high-grade localized prostate cancers. more...

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by genome tiling array

4 related Platforms
244 Samples

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Accession:: GSE35988

ID:: 200035988

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000090752.

Agilent-014698 Human Genome CGH Microarray 105A (G4412A) [Probe Name version]

(Submitter supplied) This kit provides two arrays per slide, each containing over 99,000 60-mer oligonucleotide probes. These probes, specifically optimized for copy-number measurement, span coding and non-coding genomic sequences with median spacing of 18.9 kb and 50.6 kb respectively. This microarray is designed for use with Agilent’s optimized assay protocols, enabling researchers to use nanogram levels of total genomic DNA without complexity reduction. more...