GSM843466[Accession] - GEO DataSets

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Items: 4

Select item 2000341761.

Gene expression profiling of two diffuse large B-cell lymphoma (DLBCL) cell lines, DHL4 and DHL6, treated with the SYK inhibitor, R406

(Submitter supplied) The two DLBCL cell lines were treated with R406 to assess the signature of SYK inhibition. In previous studies, R406 decreased the proliferation and induced apoptosis of these surface Ig+ cell lines. In the previous studies, R406 inhibited the autophosphorylation of SYK 525/526 and SYK-dependent phosphorylation of BCR signaling components such as BLNK.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4976
Platform:: GPL3921
29 Samples

Download data: CEL

Series

Accession:: GSE34176

ID:: 200034176

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 49762.

Spleen tyrosine kinase inhibitor effect on diffuse large B-cell lymphoma cell lines: time course

Analysis of the DHL4 and DHL6 diffuse large B-cell lymphoma (DLBCL) cell lines following treatment with R406, a spleen tyrosine kinase (SYK) inhibitor. SYK is a key component of BCR signaling which is a critical pathway in DLBCL. Results provide insight into the role of SYK in DLBCL pathogenesis.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent, 2 cell line, 5 time sets

Platform:: GPL3921
Series:: GSE34176
29 Samples

Download data: CEL

DataSet

Accession:: GDS4976

ID:: 4976

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 1000039213.

[HT_HG-U133A] Affymetrix HT Human Genome U133A Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html The GeneChip® HT Human Genome U133 Array Plate Set enables researchers to perform large-scale studies by analyzing whole-genome expression for up to 96 samples at a time. The set comprises a U133A and U133B plate, measuring expression levels for more than 33,000 well-characterized genes and UniGene clusters. more...