GSM817258[Accession] - GEO DataSets

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Items: 4

Select item 2000330751.

Imatinib therapy of chronic myeloid leukemia restores the expression levels of key genes for DNA damage and cell cycle progression

(Submitter supplied) Background: Chronic myeloid leukemia (CML) is a malignant clonal disorder of the hematopoietic system caused by the expression of the BCR/ABL fusion oncogene. It is well known that CML cells are genetically unstable. However, the mechanisms by which these cells acquire genetic alterations are poorly understood. Imatinib mesylate (IM) is the standard therapy for newly diagnosed CML patients. IM targets the oncogenic kinase activity of BCR-ABL. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4869
Platform:: GPL570
27 Samples

Download data: CEL

Series

Accession:: GSE33075

ID:: 200033075

Select item 48692.

Imatinib mesylate effect on bone marrow hematopoietic cells of chronic myeloid leukemia patients

Analysis of bone marrow hematopoietic cells in chronic myeloid leukemia (CML) patients one month after imatinib mesylate (IM) therapy. CML is caused by expression of the BCR/ABL fusion oncogene. Results provide insight into the molecular consequences of IM blockade of oncoprotein Bcr-Abl in CML.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 10 age, 10 gender, 10 individual, 3 protocol sets

Platform:: GPL570
Series:: GSE33075
27 Samples

Download data: CEL

DataSet

Accession:: GDS4869

ID:: 4869

Select item 1000005703.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...