GEO DataSets

(Submitter supplied) Inactivation of the von Hippel-Lindau tumor suppressor gene, VHL, is an archetypical tumor-initiating event in clear cell renal carcinoma (ccRCC) that leads to the activation of hypoxia-inducible transcription factors (HIFs). However, VHL mutation status in ccRCC is not correlated with clinical outcome. Here we show that during ccRCC progression, cancer cells exploit diverse epigenetic alterations to empower a branch of the VHL-HIF pathway for metastasis, and the strength of this activation is associated with poor clinical outcome. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL6791 GPL14604

26 Samples

Download data: CEL

(Submitter supplied) Inactivation of the von Hippel-Lindau tumor suppressor gene, VHL, is an archetypical tumor-initiating event in clear cell renal carcinoma (ccRCC) that leads to the activation of hypoxia-inducible transcription factors (HIFs). However, VHL mutation status in ccRCC is not correlated with clinical outcome. Here we show that during ccRCC progression, cancer cells exploit diverse epigenetic alterations to empower a branch of the VHL-HIF pathway for metastasis, and the strength of this activation is associated with poor clinical outcome. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL14604

7 Samples

Download data: CEL

(Submitter supplied) This is identical to GPL571 but a custom Brain Array CDF environment (hs133av2hsentrezgcdf version 10) was used to extract data. Protocol: Standard Affymetrix Protocol

Organism:

Homo sapiens

3 Series

1 Related Platform

2893 Samples

Download data: CDF