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Items: 3

1.

Modeling kidney development, disease, and plasticity with clonal expandable nephron progenitor cells and nephron organoids

(Submitter supplied) Nephron progenitor cells (NPCs) self-renew and differentiate into nephrons, the functional units of the kidney. Here we report manipulation of p38 and YAP activity creates a synthetic niche that allows the long-term clonal expansion of primary mouse and human NPCs, and induced NPCs (iNPCs) from human pluripotent stem cells. Cultured iNPCs resemble closely primary human NPCs, generating nephron organoids with abundant distal convoluted tubule cells, which are not observed in published kidney organoids. more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL24676
4 Samples
Download data: H5, TBI, TSV
Series
Accession:
GSE251862
ID:
200251862

PubMed Similar studies

2.

Illumina NovaSeq 6000 (Homo sapiens)

Organism:
Homo sapiens
17332 Series
938403 Samples
Download data
Platform
Accession:
GPL24676
ID:
100024676

3.

iNPC derived organoid, Replicate 2 d21, ATAC Library

Organism:
Homo sapiens
Source name:
Kidney organoids
Platform:
GPL24676
Series:
GSE251862
Download data
Sample
Accession:
GSM7989241
ID:
307989241

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