GSM79065[Accession] - GEO DataSets

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Items: 4

Select item 2000034911.

Interindividual Variability in LPS Responses

(Submitter supplied) We used an unbiased approach to identify differences in gene expression that may account for the high degree of interindividual variability in inflammatory responses to LPS in the normal human population. We measured LPS-induced cytokine production ex vivo in whole blood from 102 healthy human subjects and identified individuals who consistently showed either very high or very low responses to LPS. Comparison of gene expression profiles between the lpshigh and lpslow individuals revealed 80 genes that were differentially expressed in the presence of LPS and 21 genes that were differentially expressed in the absence of LPS (p < 0.005, ANOVA). Expression of a subset of these genes was confirmed using real-time RT-PCR. These data illustrate a novel approach to the identification of factors that determine interindividual variability in innate immune inflammatory responses. Keywords: comparative response

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS1407
Platform:: GPL8300
12 Samples

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Series

Accession:: GSE3491

ID:: 200003491

Select item 14072.

Leukocyte inflammatory responses to lipopolysaccharide

Analysis of whole blood following 4 hour treatment with lipolysaccharide (LPS). Leukocytes from individuals with high and low responses to LPS examined. LPS response assessed by measuring cytokine production. Results provide insight into the variability of LPS responses between individuals.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent, 2 other sets

Platform:: GPL8300
Series:: GSE3491
12 Samples

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DataSet

Accession:: GDS1407

ID:: 1407

Select item 1000083003.

[HG_U95Av2] Affymetrix Human Genome U95 Version 2 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 08, 2012: annotation table updated with netaffx build 32 June 27, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Based on this UniGene build and associated annotations, the HG-U95Av2 array represents approximately 10,000 full-length genes. more...