GSM7868459[Accession] - GEO DataSets

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Items: 4

Select item 2002464131.

The H2Bub1-deposition complex is required for human and mouse cardiogenesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
63 Samples

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Series

Accession:: GSE246413

ID:: 200246413

PubMed Full text in PMC Similar studies

Select item 2002464102.

The H2Bub1-deposition complex is required for human and mouse cardiogenesis (ChIP-Seq)

(Submitter supplied) De novo variants affecting monoubiquitination of histone H2B (H2Bub1) are enriched in human congenital heart disease. H2Bub1 is required in stem cell differentiation, cilia function, post-natal cardiomyocyte maturation, and transcriptional elongation. However, how H2Bub1 affects cardiogenesis is unknown. We show that the H2Bub1-deposition complex (RNF20-RNF40-UBE2B) is required for mouse cardiogenesis and for differentiation of human iPSCs into cardiomyocytes. more...