GSM782294[Accession] - GEO DataSets

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Items: 4

Select item 2000315031.

Exposure to Nickel, Chromium, or Cadmium Causes Distinct Changes in the Gene Expression Patterns of a Rat Liver Derived Cell Line

(Submitter supplied) Many heavy metals, including nickel (Ni), cadmium (Cd), and chromium (Cr) are toxic industrial chemicals with an exposure risk in both occupational and environmental settings that may cause harmful outcomes. While these substances are known to produce adverse health effects leading to disease or health problems, the detailed mechanisms remain unclear. To elucidate the processes involved in the of toxicity of nickel, cadmium, and chromium at the molecular level and to perform a comparative analysis, H4-II-E-C3 rat liver-derived cell lines were treated with soluble salts of each metal using concentrations derived from viability assays, and gene expression patterns were determined with DNA microarrays. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS3928
Platform:: GPL1355
44 Samples

Download data: CEL

Series

Accession:: GSE31503

ID:: 200031503

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 39282.

Heavy metal effect on liver derived cell line H4-II-E-C3

Analysis of H4-II-E-C3 liver-derived cells exposed to toxic heavy metals: nickel II chloride (NiCl2), cadmium chloride (CdCl2), or sodium dichromate (Na2Cr2O7), at various concentrations (based on viability assays). Results provide insight into molecular mechanisms underlying Ni, Cd and Cr toxicity.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, transformed count, 4 agent, 10 dose sets

Platform:: GPL1355
Series:: GSE31503
44 Samples

Download data: CEL

DataSet

Accession:: GDS3928

ID:: 3928

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 1000013553.

[Rat230_2] Affymetrix Rat Genome 230 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 27, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The GeneChip Rat Genome 230 2.0 Array is a powerful tool for toxicology, neurobiology, and other applications using rat as a model organism. more...