GSM780710[Accession] - GEO DataSets

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Items: 4

Select item 2000314321.

Defining the molecular response to trastuzumab, pertuzumab and combination therapy in ovarian cancer

(Submitter supplied) The purpose of this study was to characterise the effects of trastuzumab and pertuzumab, either as single agents or as combination therapy on gene and protein expression in human ovarian cancer in vivo. Illumina BeadChips were used to profile the transcriptome after four days treatment of SKOV3 tumor xenografts. Although genes involved with HER2, MAP-kinase and p53 signaling pathways were commonly induced by all treatments, a greater number and variety of genes were differentially expressed by the complementary combination therapies compared to either drug on its own. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4814
Platform:: GPL6947
23 Samples

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Series

Accession:: GSE31432

ID:: 200031432

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 48142.

Ovarian cancer xenograft tumor response to trastuzumab and pertuzumab

Analysis of SKOV3 ovarian cancer xenograft tumors treated with trastuzumab (TZ), pertuzumab (PZ), or both. TZ and PZ target Human Epidermal Growth Factor Receptor 2 (HER2). Combined therapy results in enhanced antitumor activity. Results provide insight into the molecular basis of this enhancement.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 4 agent sets

Platform:: GPL6947
Series:: GSE31432
23 Samples

Download data

DataSet

Accession:: GDS4814

ID:: 4814

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 1000069473.

Illumina HumanHT-12 V3.0 expression beadchip

(Submitter supplied) The HumanHT-12 V3.0 Expression BeadChip features up-to-date content derived from the National Center for Biotechnology Information Reference Sequence (NCBI RefSeq) database (Build 36.2, Release 22). Please use the GEO Data Submission Report Plug-in v1.0 for Gene Expression which may be downloaded from https://icom.illumina.com/icom/software.ilmn?id=234 to format the normalized and raw data. These should be submitted as part of a GEOarchive. more...