GSM7488404[Accession] - GEO DataSets

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Items: 4

Select item 2002350021.

Genome-scale chromatin interaction dynamic measurements for key components of the RNA Pol II general transcription machinery

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Schizosaccharomyces pombe; Saccharomyces cerevisiae

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL19756 GPL31112 GPL29170
119 Samples

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Accession:: GSE235002

ID:: 200235002

PubMed Full text in PMC Similar studies

Select item 2002350002.

Genome-scale chromatin interaction dynamic measurements for key components of the RNA Pol II general transcription machinery [ChIP-seq]

(Submitter supplied) A great deal of work has revealed in structural detail the components of the machinery responsible for mRNA gene transcription initiation. These include the general transcription factors (GTFs) which assemble at promoters along with RNA Polymerase II (Pol II) to form a preinitiation complex (PIC) aided by the activities of cofactors and site-specific transcription factors (TFs). However, less well understood are the in vivo PIC assembly pathways and their kinetics, an understanding of which is vital for determining on a mechanistic level how rates of in vivo RNA synthesis are established and how cofactors and TFs impact them. more...