GEO DataSets

(Submitter supplied) Homeodomains (HDs) are the second largest class of DNA binding domains (DBDs) in eukaryotic sequence-specific transcription factors (TFs) and are the TF structural class with the largest number of disease mutations in the Human Gene Mutation Database (HGMD). Despite numerous structural studies and large-scale analyses of HD DNA binding specificity, HD-DNA recognition is still not fully understood. Here, we analyzed 92 human HD mutants, including disease-associated variants and variants of unknown significance (VUS), for their effects on DNA binding activity. more...

Organism:

synthetic construct; Homo sapiens

Type:

Genome binding/occupancy profiling by array

Platform:

GPL33450

122 Samples

Download data: GPR, XLS

(Submitter supplied) In situ oligosynthesized array with synthetic sequences that cover all possible 10-mers (Berger et al., Nature Biotechnology 2006). AMADID #030236

Organism:

synthetic construct

1 Series

122 Samples

Download data