GSM73230[Accession] - GEO DataSets

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Items: 4

Select item 2000032481.

Contribution of Nuclear and Extranuclear PolyQ to Neurological Phenotypes in Mouse Models of Huntington’s Disease

(Submitter supplied) To dissect the impact of nuclear and extranuclear mutant htt on the initiation and progression of disease, we generated a series of transgenic mouse lines in which nuclear localization (NLS) or nuclear export sequences (NES) have been placed N-terminal to the htt exon 1 protein carrying 144 glutamines. Our data indicate that the exon 1 mutant protein is present in the nucleus as part of an oligomeric or aggregation complex. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2169
Platform:: GPL81
48 Samples

Download data: CEL, EXP

Series

Accession:: GSE3248

ID:: 200003248

Select item 21692.

Nuclear and extranuclear mutant huntingtin exon 1 protein effect on cerebellum

Analysis of cerebella of transgenics expressing mutant huntingtin (htt) exon 1 protein in nucleus only or in both nucleus and cytoplasm. The polyglutamine (polyQ) expansion in htt results in Huntington's disease (HD). Results provide insight into the impact of subcellular location of polyQ in HD.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 6 age, 3 agent, 5 strain sets

Platform:: GPL81
Series:: GSE3248
48 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS2169

ID:: 2169

Select item 1000000813.

[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 24, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The MG-U74 set includes 3 arrays with a total of 36899 entries and was indexed 29-Jan-2002. more...