GEO DataSets

(Submitter supplied) Mutations in the parkin gene, which encodes a ubiquitin ligase, are a major genetic cause of parkinsonism. Interestingly, parkin also plays a role in cancer as a putative tumor suppressor, and the gene is frequently targeted by deletion and inactivation in human malignant tumors. Here, we investigated a potential tumor suppressor role for parkin in gliomas. We found that parkin expression was dramatically reduced in glioma cells. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4476

Platform:

GPL6244

21 Samples

Download data: CEL

Analysis of U87MG glioma cells stably expressing parkin or vector alone. Parkin expression is dramatically reduced in glioma cells. Parkin mutations are a major cause of parkinsonism. Results provide insight into tumor suppressor function of parkin in brain tumors.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL6244

Series:

GSE29494

21 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 18, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site

Organism:

Homo sapiens

136 DataSets

1879 Series

27 Related Platforms

38399 Samples

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