GEO DataSets

(Submitter supplied) Thyroid hormone receptors (TRs) are hormone-regulated transcription factors that regulate a diverse array of biological activities, including metabolism, homeostasis, and development. TRs also serve as tumor suppressors, and aberrant TR function (via mutation, deletion, or altered expression) is associated with a spectrum of both neoplastic and endocrine diseases. A particularly high frequency of TR mutations has been reported in renal clear cell carcinoma (RCCC) and in hepatocellular carcinoma (HCC). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3945

Platform:

GPL6244

42 Samples

Download data: CEL

Analysis of HepG2 transformants expressing: wildtype thyroid hormone receptors (TRs), hepatocellular carcinoma (HCC)-TR mutants, or renal clear cell carcinoma (RCCC)-TR mutants, in the presence of hormone agonist T3 thyronine. Results provide insight into a unique regulatory repertoire for RCCCs.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 7 genotype/variation sets

Platform:

GPL6244

Series:

GSE29159

42 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 18, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site

Organism:

Homo sapiens

136 DataSets

1879 Series

27 Related Platforms

38399 Samples

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