GEO DataSets

(Submitter supplied) Abstract: The antimalarial activity of the antibiotic thiostrepton has long been attributed to inhibition of apicoplast protein synthesis through binding of apicoplast ribosomal RNA. However, the kinetics of parasite death upon thiostrepton treatment differ from those seen for other inhibitors of apicoplast housekeeping functions. We have analysed global changes in gene expression of the malaria parasite, Plasmodium falciparum, in an attempt to shed light on the responses of the parasite to this drug. more...

Organism:

Plasmodium falciparum; Anopheles gambiae

Type:

Expression profiling by array

Dataset:

GDS4260

Platform:

GPL1321

6 Samples

Download data: CEL

Analysis of ring stage Plasmodium falciparum at 5 % parasitaemia treated with 2 uM thiostrepton, an antibiotic with antimalarial activity. Results provide insight into molecular mechanisms underlying parasite responses to the drug.

Organism:

Plasmodium falciparum; Anopheles gambiae

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL1321

Series:

GSE28701

6 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 Oct 12, 2009: annotation table updated with netaffx build 32 Protocol: see manufacturer's web site The GeneChip Plasmodium/Anopheles Genome Array includes probe sets to over 4,300 Plasmodium falciparam transcripts and approximately 14,900 Anopheles gambiae transcripts. more...

Organism:

Plasmodium falciparum; Anopheles gambiae

6 DataSets

30 Series

523 Samples

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