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Items: 4

1.

Symmetric inheritance of parental histones governs epigenome maintenance and stem cell identity

(Submitter supplied) Modified parental histones are segregated symmetrically to daughter DNA strands during replication and inherited through mitosis. How this may sustain the epigenome and cell identity remains unknown. Here, we show that transmission of histone-based information during replication maintains epigenome fidelity and embryonic stem cell plasticity. Asymmetric segregation of parental histones H3-H4 in MCM2-2A mutants compromised mitotic inheritance of histone modifications and globally altered the epigenome. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
Platforms:
GPL19057 GPL24247 GPL30172
388 Samples
Download data: BW, LOOM, MTX, TSV
Series
Accession:
GSE154391
ID:
200154391
2.

Symmetric inheritance of parental histones governs epigenome maintenance and stem cell identity [RNA-seq]

(Submitter supplied) Modified parental histones are segregated symmetrically to daughter DNA strands during replication and inherited through mitosis. How this may sustain the epigenome and cell identity remains unknown. Here, we show that transmission of histone-based information during replication maintains epigenome fidelity and embryonic stem cell plasticity. Asymmetric segregation of parental histones H3-H4 in MCM2-2A mutants compromised mitotic inheritance of histone modifications and globally altered the epigenome. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL30172 GPL19057
68 Samples
Download data: TXT
Series
Accession:
GSE154390
ID:
200154390
3.

NextSeq 2000 (Mus musculus)

Platform
Accession:
GPL30172
ID:
100030172
4.

RNA_442_rescue_exp_r4_tech2

Organism:
Mus musculus
Source name:
E14JU
Platform:
GPL30172
Series:
GSE154390 GSE154391
Download data
Sample
Accession:
GSM7018440
ID:
307018440

Supplemental Content

db=gds|term=GSM7018440[Accession]|query=1|qty=2|blobid=MCID_675d03b462eb871759a19f6d|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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