GSM687694[Accession] - GEO DataSets

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Items: 4

Select item 2000278581.

The novel antisense Bcl-2 inhibitor SPC2996 causes rapid leukemic cell clearance and immune activation in chronic lymphocytic leukemia

(Submitter supplied) SPC2996 is a novel locked nucleic acid (LNA) phosphorothioate antisense molecule targeting the mRNA of the Bcl-2 oncoprotein. We investigated the mechanism of action of SPC2996 and the basis for its clinically observed immunostimulatory effects in chronic lymphocytic leukemia (CLL). Patients with relapsed CLL were treated with a maximum of six doses of SPC2996 (0.2-6mg/ kg) in a multicenter phase I trial. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4284
Platform:: GPL570
56 Samples

Download data: CEL, CHP

Series

Accession:: GSE27858

ID:: 200027858

Select item 42842.

Chronic lymphocytic leukemia response to antisense Bcl-2 inhibitor SPC2996: peripheral blood

Temporal analysis of peripheral blood from 18 relapsed CLL patients treated with a maximum of 6 doses (0.2-6mg/kg) of SPC2996, an antisense molecule targeting the mRNA of Bcl-2 oncoprotein. Results provide insight into the molecular basis of the immunostimulatory effects of SPC2996 in CLL.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 6 dose, 18 individual, 4 time sets

Platform:: GPL570
Series:: GSE27858
56 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS4284

ID:: 4284

Select item 1000005703.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...