GSM685749[Accession] - GEO DataSets

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Items: 4

Select item 2000276861.

Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes molecularly distinct from physiologic stem cell aging

(Submitter supplied) Somatic stem cells mediate tissue maintenance for the lifetime of an organism. Despite the well-established longevity that is a prerequisite for such function, accumulating data argue for compromised stem cell function with age. Identifying the mechanisms underlying age-dependent stem cell dysfunction is therefore key to understand the aging process. Using a model that carries a proofreading defective mitochondrial DNA polymerase, we demonstrate hematopoietic defects reminiscent of premature HSC aging including anemia, lymphopenia and myeloid lineage skewing. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3976
Platform:: GPL1261
16 Samples

Download data: CEL

Series

Accession:: GSE27686

ID:: 200027686

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 39762.

Premature Hematopoietic Aging model: bone marrow hematopoietic stem cells

Analysis of hematopoietic stem cells (HSCs) from mid-aged mutator females that express a proofreading-defective form of the mitochondrial DNA polymerase gamma (POLG). Results provide insight into the molecular mechanisms underlying multiple aspects of aging accelerated in the mutator model.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 3 age, 2 cell type, 5 genotype/variation sets

Platform:: GPL1261
Series:: GSE27686
16 Samples

Download data: CEL

DataSet

Accession:: GDS3976

ID:: 3976

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 1000012613.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...