GEO DataSets

(Submitter supplied) Using EphB2 or the ISC marker Lgr5, we have FACS-purified and profiled intestinal stem cells (ISCs), crypt proliferative progenitors and late transient amplifying cells to define a gene expression program specific for normal ISCs. A frequent complication in colorectal cancer (CRC) is regeneration of the tumor after therapy. The intestinal stem cell signature predicts disease relapse in CRC and identifies a stem cell-like population that displays robust tumor- initiating capacity in immunodeficient mice as well as long-term self-renewal potential.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4514

Platform:

GPL1261

8 Samples

Download data: CEL

Analysis of intestinal epithelial cells FACS-sorted according to high, medium or low EphB2 receptor levels. Intestinal stem cells (ISC) highly express EphB2 receptor which becomes gradually silenced as cells differentiate. Results provide insight into a molecular program specific for normal ISCs.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 cell type sets

Platform:

GPL1261

Series:

GSE27605

6 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...

Organism:

Mus musculus

601 DataSets

4547 Series

40 Related Platforms

58950 Samples

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