GSM664755[Accession] - GEO DataSets

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Items: 4

Select item 2000269871.

The kinases MEKK2 and MEKK3 regulate Transforming Growth Factor-β-mediated helper T cell differentiation

(Submitter supplied) Mitogen-activated protein kinases (MAPKs) are key mediators of the T cell receptor (TCR) signals but their roles in T helper (Th) cell differentiation are unclear. Here we showed that the MAPK kinase kinases MEKK2 (encoded by Map3k2) and MEKK3 (encoded by Map3k3),negatively regulated transforming growth factor-beta (TGF-beta)-mediated Th cell differentiation.Map3k2-/-Map3k3Lck-Cre/- mice showed an abnormal accumulation of regulatory T (Treg) and Th17 cells in the periphery, consistent with Map3k2-/-Map3k3Lck-Cre/- naïve CD4+ T cells' differentiation into Treg and Th17 cells with a higher frequency than wild-type (WT) cells after TGF-beta stimulation in vitro. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4795
Platform:: GPL6887
4 Samples

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Series

Accession:: GSE26987

ID:: 200026987

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 47952.

MEKK2 and MEKK3 deficiency effect on CD26L(low)CD44(high) CD4 T cells

Analysis of CD26L(low)CD44(high) CD4(+) T cells deficient for MEKK2 and MEKK3, conserved members of the MEK kinase (MEKK) subgroup of the MAP3K superfamily. Results provide insight into the role of MEKK2 and MEKK3 in helper T cell differentiation.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation sets

Platform:: GPL6887
Series:: GSE26987
4 Samples

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DataSet

Accession:: GDS4795

ID:: 4795

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 1000068873.

Illumina MouseWG-6 v2.0 expression beadchip

(Submitter supplied) The MouseWG-6 v2.0 Expression BeadChip offer the most up-to-date content for whole-genome expression profiling in the mouse. Featuring content derived from the National Center for Biotechnology Information Reference Sequence (NCBI RefSeq) database (Build 36, Release 22). Please use the GEO Data Submission Report Plug-in v1.0 for Gene Expression which may be downloaded from https://icom.illumina.com/icom/software.ilmn?id=234 to format the normalized and raw data. more...