GEO DataSets

(Submitter supplied) The molecular explanation for tamoxifen serving as a breast cancer treatment but displaying partial estrogenic in the uterus is not known. Previously, we reported that differential promoter context and cofactor recruitment contribute to the tissue specificity of tamoxifen. Here, we investigated the genomic basis for the partial oestrogenic activity of tamoxifen in the endometrium. We showed that tamoxifen not only affects the rate of transcription of oestrogen target genes but also targets a unique set of genes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS1510 GDS3604

Platforms:

GPL8300 GPL91

18 Samples

Download data: CEL, EXP

Analysis of endometrial epithelial cells from stage I or II endometrioid carcinomas after treatment with oestrogen or tamoxifen (TMX). Results provide insight into the molecular basis of the association of TMX treatment of breast cancer with an increased incidence of endometrial cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 agent, 2 disease state sets

Platform:

GPL8300

Series:

GSE3013

7 Samples

Download data: CEL, EXP

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 08, 2012: annotation table updated with netaffx build 32 June 27, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Based on this UniGene build and associated annotations, the HG-U95Av2 array represents approximately 10,000 full-length genes. more...

Organism:

Homo sapiens

99 DataSets

302 Series

6446 Samples

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