GEO DataSets

(Submitter supplied) We aimed to identify specific biomarkers of IFN-beta bioactivity in order to compare their gene expression induction by type I IFNs with the MxA, and to investigate their potential role in MS pathogenesis. Gene expression microarrays were performed in PBMC from MS patients who developed neutralizing antibodies (NAB) to IFN-beta. Nine genes followed patterns in gene expression over time similar to the MX1 and were selected for further experiments: IFI6, IFI27, IFI44L, IFIT1, HERC5, LY6E, RSAD2, SIGLEC1, and USP18. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4147

Platform:

GPL570

32 Samples

Download data: CEL

Temporal analysis of PBMCs from relapsing-remitting multiple sclerosis (RRMS) patients treated with Interferon-β-1b (Betaferon) or IFNβ-1a (Rebif). Half of the patients developed neutralizing antibodies (NAB) to IFNβ. Results provide insight into molecular basis of IFNβ bioactivity in MS patient

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 agent, 2 individual, 4 time sets

Platform:

GPL570

Series:

GSE26104

32 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...

Organism:

Homo sapiens

602 DataSets

5671 Series

61 Related Platforms

175585 Samples

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