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Items: 4

1.

Comparative transcriptome profiling of Amyloid Precursor Protein APP family members in the adult cortex

(Submitter supplied) The β-amyloid precursor protein APP and the related APLPs, undergo complex proteolytic processing giving rise to several fragments. Whereas it is well established that Aβ accumulation is a central trigger for Alzheimer disease (AD), the physiological role of APP family members and their diverse proteolytic products is still largely unknown. The secreted APPsα ectodomain has been shown to be involved in neuroprotection and synaptic plasticity. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4414
Platform:
GPL1261
15 Samples
Download data: CEL
Series
Accession:
GSE25926
ID:
200025926
2.
Full record GDS4414

Amyloid Precursor Protein APP family members: adult prefrontal cortex

Analysis of prefrontal cortex of adult wild-type, APP knockout, APLP2 knockout, and APPsα knockin (solely expressing the secreted APPsα ectodomain) males. β-amyloid accumulation is a key trigger for Alzheimer's disease. Results provide insight into physiological functions of APP family members.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 4 genotype/variation, 2 strain sets
Platform:
GPL1261
Series:
GSE25926
15 Samples
Download data: CEL
3.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...
Organism:
Mus musculus
601 DataSets
4547 Series
40 Related Platforms
58950 Samples
Download data
Platform
Accession:
GPL1261
ID:
100001261
4.

APPsa_R6_rep2

Organism:
Mus musculus
Source name:
APPsa_R6
Platform:
GPL1261
Series:
GSE25926
Dataset:
GDS4414
Download data: CEL
Sample
Accession:
GSM636867
ID:
300636867
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