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Items: 4

1.

Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Rattus norvegicus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
4 related Platforms
41 Samples
Download data: BIGWIG
Series
Accession:
GSE205838
ID:
200205838
2.

Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation [RNA-Seq 1]

(Submitter supplied) Propiogenic substrate catabolism and gut bacteria produce propionate, a post-translational protein modifier. Here, using a mouse model of propionic acidaemia (PA), we characterise how disturbances to propionate metabolism modify histones and affect cardiac gene expression and function. Plasma propionate was raised in PA mice, but male hearts accumulated a smaller propionyl-CoA excess, correlating with -alanine build-up. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
20 Samples
Download data: CSV, TXT
Series
Accession:
GSE205834
ID:
200205834
3.

Illumina NovaSeq 6000 (Mus musculus)

Platform
Accession:
GPL24247
ID:
100024247
4.

RNA_amPA-M_rep1

Organism:
Mus musculus
Source name:
polyA RNA-seq in Pcca-/- male 8-week-old mouse heart
Platform:
GPL24247
Series:
GSE205834 GSE205838
Download data
Sample
Accession:
GSM6234266
ID:
306234266
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Supplemental Content

db=gds|term=GSM6234266[Accession]|query=1|qty=3|blobid=MCID_6749378486d4ad4f7f59fdfa|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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