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Items: 3

1.

RNA Polymerase I activity prevents terminal differentiation and growth arrest in colorectal cancer and induce vulnerability for senolytics

(Submitter supplied) Loss of the tumor suppressor APC, which constitutes the initiating event in the adenoma carcinoma sequence for colorectal cancer (CRC), induces expression of RNA polymerase I (RNAPOL1) transcription machinery and subsequently upregulates rDNA transcription. Targeting RNAPOL1 with a specific inhibitor, CX5461, disrupts nucleolar integrity and induces a disbalance of ribosomal proteins. CX5461-induced growth arrest is irreversible, and exhibits features of senescence as well as terminal differentiation. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
12 Samples
Download data: TXT
Series
Accession:
GSE204749
ID:
200204749

PubMed Full text in PMC Similar studies Analyze with GEO2R

2.

Illumina NextSeq 500 (Homo sapiens)

Organism:
Homo sapiens
12629 Series
344269 Samples
Download data
Platform
Accession:
GPL18573
ID:
100018573

3.

AB183_72H_R1

Organism:
Homo sapiens
Source name:
LS174T cells
Platform:
GPL18573
Series:
GSE204749
Download data
Sample
Accession:
GSM6190595
ID:
306190595

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db=gds|term=GSM6190595[Accession]|query=1|qty=2|blobid=MCID_67503df67c96e17d293d7d76|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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