GSM6045704[Accession] - GEO DataSets

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Items: 4

Select item 2002008751.

Lola-I is a promoter pioneer factor that establishes de novo Pol II pausing during development

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL19132 GPL13304
122 Samples

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Accession:: GSE200875

ID:: 200200875

PubMed Full text in PMC Similar studies

Select item 2002008672.

Lola-I is a promoter pioneer factor that establishes de novo Pol II pausing during development [ATAC-seq]

(Submitter supplied) While enhancers are often regulated at the level of accessibility by pioneer factors, promoters tend to be constitutively accessible and poised for activation by paused Pol II — thus are often not considered as sites of developmental regulation. Here we show that the accessibility of promoters and the acquisition of paused Pol II can also be subject to developmental regulation by pioneer factors. We show that Lola-I, a Drosophila zinc finger transcription factor, is ubiquitously expressed at the end of embryogenesis and causes its target promoters to become accessible and acquire paused Pol II throughout the embryo. more...