U.S. flag

An official website of the United States government

Format
Sort by

Send to:

Choose Destination

Search results

Items: 4

1.

Symmetric inheritance of parental histones governs epigenome maintenance and stem cell identity

(Submitter supplied) Modified parental histones are segregated symmetrically to daughter DNA strands during replication and inherited through mitosis. How this may sustain the epigenome and cell identity remains unknown. Here, we show that transmission of histone-based information during replication maintains epigenome fidelity and embryonic stem cell plasticity. Asymmetric segregation of parental histones H3-H4 in MCM2-2A mutants compromised mitotic inheritance of histone modifications and globally altered the epigenome. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
Platforms:
GPL24247 GPL19057 GPL30172
388 Samples
Download data: BW, LOOM, MTX, TSV
Series
Accession:
GSE154391
ID:
200154391

PubMed Full text in PMC Similar studies

2.

Symmetric inheritance of parental histones governs epigenome maintenance and stem cell identity [RNA-seq]

(Submitter supplied) Modified parental histones are segregated symmetrically to daughter DNA strands during replication and inherited through mitosis. How this may sustain the epigenome and cell identity remains unknown. Here, we show that transmission of histone-based information during replication maintains epigenome fidelity and embryonic stem cell plasticity. Asymmetric segregation of parental histones H3-H4 in MCM2-2A mutants compromised mitotic inheritance of histone modifications and globally altered the epigenome. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL30172 GPL19057
68 Samples
Download data: TXT
Series
Accession:
GSE154390
ID:
200154390

PubMed Full text in PMC Similar studies SRA Run Selector

3.

Illumina NextSeq 500 (Mus musculus)

Organism:
Mus musculus
10344 Series
296979 Samples
Download data
Platform
Accession:
GPL19057
ID:
100019057

4.

RNA_410_r1_POLE4-KO_exp

Organism:
Mus musculus
Source name:
Embryonic stem cells
Platform:
GPL19057
Series:
GSE154390 GSE154391
Download data
Sample
Accession:
GSM5859081
ID:
305859081

SRA Run Selector

Format
Sort by

Send to:

Choose Destination

Supplemental Content

Filters: Manage Filters

db=gds|term=GSM5859081[Accession]|query=1|qty=2|blobid=MCID_675034fb7c96e17d293c2a28|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Search details

See more...

Important Links

Recent activity

Clear Turn Off Turn On

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
You are here: NCBI > Genes & Expression > Gene Expression Omnibus (GEO) Datasets
Support Center