GSM5627298[Accession] - GEO DataSets

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Items: 4

Select item 2001859681.

Age-dependent Lamin remodeling induces cardiac dysfunction via dysregulation of cardiac transcriptional programs

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL19132 GPL25244
45 Samples

Download data: NARROWPEAK

Series

Accession:: GSE185968

ID:: 200185968

Select item 2001859232.

Age-dependent Lamin remodeling induces cardiac dysfunction via dysregulation of cardiac transcriptional programs [ATAC-Seq]

(Submitter supplied) As we age, structural changes contribute to progressive decline in organ function, which in the heart acts through poorly characterized mechanisms. Utilizing the rapidly aging fruit fly model with its significant homology to the human cardiac proteome, we found that cardiomyocytes exhibit progressive loss of Lamin C (mammalian Lamin A/C homologue) with age. Unlike other tissues and laminopathies, we observe decreasing nuclear size, while nuclear stiffness increases. more...