GSM5392490[Accession] - GEO DataSets

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Items: 4

Select item 2001784901.

Inactivation of the histone H3 K36 methyltransferase NSD1 confers resistance to EZH2 inhibition

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
108 Samples

Download data: BED, BW, NARROWPEAK

Series

Accession:: GSE178490

ID:: 200178490

PubMed Full text in PMC Similar studies

Select item 2001784882.

Inactivation of the histone H3 K36 methyltransferase NSD1 confers resistance to EZH2 inhibition [RNA-Seq]

(Submitter supplied) Disruption of antagonism between SWI/SNF chromatin remodelers and Polycomb repressor complexes drives the formation of numerous cancer types. Recently, an inhibitor of Polycomb protein EZH2 was approved for treatment of sarcomas mutant in SWI/SNF subunit SMARCB1, but resistance occurs. Here we sought to identify additional contributors to SWI/SNF-Polycomb antagonism and potential resistance mechanisms. more...