GEO DataSets

(Submitter supplied) Lung disease causes most of the morbidity and mortality in cystic fibrosis (CF). However, understanding its pathogenesis has been hindered by lack of an animal model with characteristic features of CF. To overcome this problem, we recently generated pigs with targeted CFTR genes. We now report that within months of birth, CF pigs spontaneously develop hallmark features of CF lung disease including airway inflammation, remodeling, mucus accumulation, and infection. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Dataset:

GDS4247

Platform:

GPL3533

40 Samples

Download data: CEL

Analysis of trachea, bronchus and distal lung from newborn pigs with cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations. Cystic fibrosis (CF) pigs develop lung disease. Results provide insight into CF lung disease pathogenesis.

Organism:

Sus scrofa

Type:

Expression profiling by array, count, 2 disease state, 2 genotype/variation, 3 tissue sets

Platform:

GPL3533

Series:

GSE21071

40 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html The GeneChip Porcine Genome Array provides comprehensive coverage of the Sus scrofa transcriptome. The array contains 23,937 probe sets that interrogate approximately 23,256 transcripts from 20,201 S. scrofa genes. The sequence information for this array was selected from public data sources including UniGene Build 28 (August 2004), GenBank® mRNAs up to August 24, 2004, and GenBank porcine mitochondrial and rRNA sequences. more...

Organism:

Sus scrofa

8 DataSets

177 Series

3844 Samples

Download data