GSM5238997[Accession] - GEO DataSets

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Items: 3

Select item 2001719651.

Mutant p53 mediates sensitivity to cancer treatment agents in oesophageal adenocarcinoma associated with microRNA and SLC7A11 expression

(Submitter supplied) 1) Background: TP53 gene mutations occur in 70% of oesophageal adenocarcinomas (OACs). Given the central role of p53 in controlling cellular response to therapy we investigated the role of mutant (mut-) p53 and SLC7A11 in a CRISPR-mediated JH-EsoAd1 TP53 knockout model. (2) Methods: Response to 2 Gy irradiation, cisplatin, 5-FU, 4-hydroxytamoxifen and endoxifen was assessed, followed by a TaqMan OpenArray qPCR screening for differences in miRNA expression. more...

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL22992
22 Samples

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Accession:: GSE171965

ID:: 200171965

PubMed Full text in PMC Similar studies

Select item 1000229922.

TaqMan OpenArray Human MicroRNA Panel

(Submitter supplied) see manufacturer's website: http://www.lifetechnologies.com/

Organism:: Homo sapiens

13 Series
295 Samples

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Accession:: GPL22992

ID:: 100022992

Select item 3052389973.

Cas-9 only clonal cell line, mutant-p53, experiment-3

Organism:: Homo sapiens

Source name:: JH-EsoAd1 cell line derived from a patient with Barrett-associated adenocarcinoma, which has a missense c797G>A mutation in TP53 resulting in an amino acid change of G266E