GSM515971[Accession] - GEO DataSets

Select item 2000322461.

TET2 mutations in acute myeloid leukemia: Results from a comprehensive genetic and clinical analysis of the AML Study Group (AMLSG)

(Submitter supplied) Purpose: The tet oncogene family member 2 (TET2) gene was recently identified mutated in myeloid disorders including acute myeloid leukemia (AML). To date, there is increasing evidence for a functional role of TET2 mutations (TET2mut) in AML. Thus, we explored frequency, gene expression pattern, and clinical impact of TET2mut in a large cohort of AML patients, in the context of other AML-associated aberrations. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

9 related Platforms
333 Samples

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Series

Accession:: GSE32246

ID:: 200032246

Select item 2000231432.

Common and overlapping oncogenic pathways contribute to the evolution of acute myeloid leukemias.

(Submitter supplied) In this report we demonstrate that the ability to alter self-renewal in vitro and in vivo is a more generalized property of leukemia-associated oncogenes. We further demonstrate that disparate leukemia-associated oncogenes initiate early common and overlapping transformation and self-renewal gene expression programs to mediate these effects. Furthermore, elements of these programs can be detected in established leukemia stem cells from an animal model and across a large cohort of patients with differing acute myeloid leukemia (AML) subtypes, where they strongly predict for disease biology. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

5 related Platforms
253 Samples

Download data: TXT

Series

Accession:: GSE23143

ID:: 200023143

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000233123.

RUNX1 mutated cases in acute myeloid leukemia share a distinct biological subgroup and are associated with inferior outcome. Results of the AML Study Group (AMLSG).

(Submitter supplied) PURPOSE: To evaluate frequency, biological features and clinical relevance of RUNX1 mutations in acute myeloid leukemia (AML). PATIENTS AND METHODS: Diagnostic samples from 945 patients (18 to 60 years) were analyzed for RUNX1 mutations. In a subset of cases (n=269) microarray gene expression analysis was performed. RESULTS: Fifty-nine RUNX1 mutations were identified in 53 of 945 (5.6%) cases, predominantly in exons 3 (n=11), 4 (n=10) and 8 (n=23). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

9 related Platforms
269 Samples

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Series

Accession:: GSE23312

ID:: 200023312

Select item 2000227784.

Musashi 2 regulates normal hematopoiesis and accelerates leukemogenesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by array

11 related Platforms
455 Samples

Download data: CEL, TXT

Series

Accession:: GSE22778

ID:: 200022778

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000164325.

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

(Submitter supplied) RNA-binding proteins of the Musashi (Msi) family are expressed in stem cell compartments and in aggressive tumors, but they have not yet been widely explored in the blood. Here we demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSCs), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo. Overexpression of human MSI2 in a mouse model increases HSC cell cycle progression and cooperates with the chronic myeloid leukemia-associated BCR-ABL1 oncoprotein to induce an aggressive leukemia. more...