(Submitter supplied) The Drosophila brain is a work horse in neuroscience. Single-cell transcriptome analysis, 3D morphological classification, and detailed mapping of the connectome have revealed an immense diversity of neuronal and glial cell types that underlie the wide array of functional and behavioral traits in the fruit fly. The developmental trajectories of each of these cell types, from neuroblast to mature neuron or glial cell, as well as their maintenance and plasticity in the adult brain, are controlled by gene regulatory networks (GRNs) In this study, we profiled chromatin accessibility of 240,000 single cells, spanning nine developmental time points from larval, pupal, and adult brains, and integrated this data with single-cell transcriptomes.
more...- Organism:
- Drosophila melanogaster
- Type:
- Genome binding/occupancy profiling by high throughput sequencing
- Platforms:
- GPL25244 GPL30203 GPL19132
- 58 Samples
Download data: BED, BW, GFF, NARROWPEAK, RDATA, RDS