GSM4915162[Accession] - GEO DataSets

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Items: 4

Select item 2001618221.

DNA replication timing directly regulates the frequency of oncogenic chromosomal translocations

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL24973 GPL17021 GPL24247
111 Samples

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Series

Accession:: GSE161822

ID:: 200161822

PubMed Similar studies

Select item 2001618182.

DNA replication timing directly regulates the frequency of oncogenic chromosomal translocations

(Submitter supplied) Chromosomal translocations result from the joining of DNA double-strand breaks (DSBs) and frequentlycause cancer. However, the steps linking DSB formation to DSB ligation remain undeciphered. Wereport that DNA replication timing (RT) directly regulates lymphomagenicMyctranslocations duringantibody maturation in B cells downstream of DSBs and independently of DSB frequency. Depletion ofminichromosome maintenance complexes alters replication origin activity, decreases translocations,and deregulates global RT. more...