GSM4566723[Accession] - GEO DataSets

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Items: 4

Select item 2001511121.

Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. For processing workflows and scripts, please refer to https://github.com/jonipsaro/asterix_gtsf1

Organism:: Spodoptera frugiperda; Drosophila melanogaster; Mus musculus

Type:: Other

Platforms:: GPL19132 GPL27985 GPL19057
24 Samples

Download data: FASTA, TXT

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Accession:: GSE151112

ID:: 200151112

PubMed Full text in PMC Similar studies

Select item 2001511092.

eCLIP of Drosophila Asterix/Gtsf1 (endogenous promoter) in Drosophila ovarian somatic sheath (OSS) cells

(Submitter supplied) Asterix/Gtsf1 has been previously been shown to be involved in the silencing of retrotransposons in animal germ cells through the piRNA pathway. Using eCLIP and a custom informatic pipeline, we found that Asterix/Gtsf1 binds directly to RNAs and preferentially interacts with tRNAs as a class. Given the role of tRNAs as primers for Long Terminal Repeat (LTR) transposons, this work implicates Asterix/Gtsf1 as exploiting tRNA dependence to identify transposon transcripts and promote piRNA silencing.