GSM4288099[Accession] - GEO DataSets

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Items: 4

Select item 2001444261.

Effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Methylation profiling by genome tiling array

Platforms:: GPL20301 GPL21145
212 Samples

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Accession:: GSE144426

ID:: 200144426

PubMed Full text in PMC Similar studies

Select item 2001444252.

Effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes [methylation]

(Submitter supplied) The predominant outcome of cardiovascular disease (CVD) is myocardial infarction (MI), where cardiomyocytes are deprived of oxygen. To study inter-individual differences in cardiomyocytes’ response to hypoxia, we established an in vitro model of induced pluripotent stem cell-derived cardiomyocytes from 15 individuals. We characterized gene expression levels, chromatin accessibility, and methylation profiles in these cardiomyocytes in four culturing conditions that correspond to normoxia (10% O2), hypoxia (1% O2) and short or long-term re-oxygenation (back to 10% O2). more...