GSM4286113[Accession] - GEO DataSets

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Items: 4

Select item 2001443341.

A unique viral reservoir landscape associated with durable natural control of HIV-1 infection

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21697
171 Samples

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Accession:: GSE144334

ID:: 200144334

PubMed Full text in PMC Similar studies

Select item 2001443322.

A unique viral reservoir landscape associated with durable natural control of HIV-1 infection [RNA-seq]

(Submitter supplied) Sustained, drug-free control of HIV-1 replication is naturally achieved in less than 0.5% of infected persons (“elite controllers”, ECs), despite the presence of a replication-competent viral reservoir. Such an ability to spontaneously maintain undetectable plasma viremia is a major objective of functional cure efforts, yet the characteristics of proviral reservoirs in ECs remain to be determined. Using single-genome, near full-length next-generation sequencing and chromosomal integration site analysis, we here show that proviral reservoirs of ECs frequently consist of oligoclonal to near monoclonal clusters of identical intact proviral sequences. more...