GSM4143595[Accession] - GEO DataSets - NCBI

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Items: 4

Select item 2001395501.

Fully defined human PSC-derived microglia and tri-culture system reveals cell type specific potentiation of complement C3 production in a model of Alzheimer’s disease [scRNA-seq]

(Submitter supplied) Aberrant inflammation in the central nervous system (CNS) has been implicated as a major player in the pathogenesis of human neurodegenerative disease. However, the specific contribution of each cell type to the neuroinflammatory axis in vivo remains unclear with species-specific differences in key signaling pathways further complicating the challenge. To assemble a fully human platform to study neuroinflammation, we first developed a novel approach to derive microglia from human pluripotent stem cells (hPSCs) that faithfully recapitulates microglial ontogeny as validated by single cell RNA-sequencing and stage-specific mapping onto datasets of developing mouse microglia. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
4 Samples

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Series

Accession:: GSE139550

ID:: 200139550

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001395522.

Fully defined human PSC-derived microglia and tri-culture system reveals cell type specific potentiation of complement C3 production in a model of Alzheimer’s disease

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL20301
27 Samples

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Series

Accession:: GSE139552

ID:: 200139552

Select item 1000246763.

Illumina NovaSeq 6000 (Homo sapiens)

Organism:: Homo sapiens

17505 Series
941220 Samples

Platform

Accession:: GPL24676

ID:: 100024676

Select item 3041435954.

Day4_macro_co-culture

Organism:: Homo sapiens

Source name:: hPSC-microglia from co-culture with hPSC-neurons

Platform:: GPL24676
Series:: GSE139550 GSE139552

Download data: CSV

Sample

Accession:: GSM4143595

ID:: 304143595

SRA Run Selector

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