GEO DataSets

(Submitter supplied) A deletion in the CMAH gene in humans occurred approximately 3.5 million years ago. This resulted in the inactivation of the CMP-Neu5Ac hydroxylase enzyme, and hence, in the specific deficiency in N-glycolylneuraminic acid (Neu5Gc), a form of sialic acid, in all modern humans. Although there is evidence that this molecular milestone in the origin of humans may have led to the evolution of human-specific pathogens, how deficiency in Neu5Gc might alter progression of non-infectious human diseases remains unanswered. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS4200 GDS4770

Platform:

GPL1261

24 Samples

Download data: CEL

Analysis of muscle from mdx males with a human-specific deletion in the Cmah (cytidine monophosphate-sialic acid hydroxylase) gene. Cmah-/-mdx mice show increased disease severity that better approximates DMD in humans. Results provide insight into the contributions of glycosylation defects to DMD.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 genotype/variation, 2 strain sets

Platform:

GPL1261

Series:

GSE16438

12 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...

Organism:

Mus musculus

601 DataSets

4547 Series

40 Related Platforms

58950 Samples

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