GSM4110143[Accession] - GEO DataSets

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Items: 4

Select item 2001386601.

Ets1 confers context-dependent activation of Notch signaling in T-cell leukemia

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array

Platforms:: GPL570 GPL21697 GPL20301
53 Samples

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Accession:: GSE138660

ID:: 200138660

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001385162.

Ets1 confers context-dependent activation of Notch signaling in T-cell leukemia [ChIP-Seq]

(Submitter supplied) Notch activation is highly prevalent in several cancers, including more than 60% of cases of T-cell acute lymphoblastic leukemia (T-ALL). However, the use of pan-Notch inhibitors to treat cancers has been hampered by excessive toxicities, particularly affecting intestinal health. In order to combat Notch-driven oncogenic signals with less toxicity, one strategy is to target the transcriptional cofactors that promote tissue-specific Notch activation. more...