GSM3747828[Accession] - GEO DataSets

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Items: 4

Select item 2001306921.

The histone deacetylase SIRT6 restrains transcription elongation via promoter-proximal pausing

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing

Platforms:: GPL17021 GPL19057
46 Samples

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Series

Accession:: GSE130692

ID:: 200130692

PubMed Full text in PMC Similar studies

Select item 2001306912.

The histone deacetylase SIRT6 controls transcription elongation via promoter-proximal pausing (PRO-Seq)

(Submitter supplied) Transcriptional regulation in eukaryotes commonly occurs at promoter-proximal regions wherein transcriptionally engaged RNA Polymerase II (Pol II) pauses before proceeding towards productive elongation. The roles of chromatin in this process remains poorly understood. Here, we demonstrate that the histone deacetylase SIRT6 regulates transcription elongation by binding to Pol II and anchoring the Negative ELongation Factor NELF, thereby preventing the release of Pol II towards elongation. more...