GSM277498[Accession] - GEO DataSets

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Items: 4

Select item 2000109721.

Colon cancer

(Submitter supplied) Genetic and epigenetic defects in Wnt/?-catenin signaling play important roles in colorectal cancer progression. Here we identify DACT3, a member of the DACT (Dpr/Frodo) gene family, as a negative regulator of Wnt/ß-catenin signaling that is transcriptionally repressed in colorectal cancer. Unlike other Wnt signaling inhibitors that are silenced by DNA methylation, DACT3 repression is associated with bivalent histone modifications. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6104
60 Samples

Download data: TXT

Series

Accession:: GSE10972

ID:: 200010972

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000109502.

Comparing gene expression in human colon tumor vs paired normal colon mucosa

(Submitter supplied) 24 colon normal and tumor pairs using Illumina BeadChip Human Ref8-v2. Genetic and epigenetic defects in Wnt/ß-catenin signaling play important roles in colorectal cancer progression. Here we identify DACT3, a member of the DACT (Dpr/Frodo) gene family, as a negative regulator of Wnt/ß-catenin signaling that is transcriptionally repressed in colorectal cancer. Unlike other Wnt signaling inhibitors that are silenced by DNA methylation, DACT3 repression is associated with bivalent histone modifications. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6104
48 Samples

Download data: TXT

Series

Accession:: GSE10950

ID:: 200010950

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000061043.

Illumina humanRef-8 v2.0 expression beadchip

(Submitter supplied) Researchers can generate whole genome expression profiles for multiple samples on a single BeadChip. Researchers can profile six or eight samples perBeadChip, with more than 22,000 transcript probes using the HumanRef-8 v2 beadchip. Please use the GEO Data Submission Report Plug-in v1.0 for Gene Expression which may be downloaded from https://icom.illumina.com/icom/software.ilmn?id=234 to format the normalized and raw data. more...