GSM2357630[Accession] - GEO DataSets

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Items: 4

Select item 2000890331.

Post-transcriptional Gene Silencing Mediated by microRNAs is Controlled by Nucleoplasmic Sfpq

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Expression profiling by array; Other; Non-coding RNA profiling by high throughput sequencing

4 related Platforms
46 Samples

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Series

Accession:: GSE89033

ID:: 200089033

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000890272.

Post-transcriptional Gene Silencing Mediated by microRNAs is Controlled by Nucleoplasmic Sfpq [HITS-CLIP]

(Submitter supplied) There is a growing body of evidence about the presence and the activity of the miRISC in the nucleus of mammalian cells. Here, we show by quantitative proteomic analysis that Ago2 interacts with nucleoplasmic Sfpq in a RNA-dependent fashion. By HITS-CLIP and transcriptomic analyses, we demonstrated that Sfpq directly controls the miRNA targeting of a subset of crucial miRNA-target mRNAs when it binds locally. more...