GEO DataSets

(Submitter supplied) Gene expression is a complex quantitative trait partially regulated by genetic variation in DNA sequence. Population differences in gene expression could contribute to some of the observed differences in susceptibility to common diseases and responses to drug treatments. We characterize gene expression in the full set of HapMap lymphoblastoid cell lines derived from individuals of European and African ancestry for 9,156 transcript clusters (gene-level) evaluated using the Affymetrix GeneChip® Human Exon 1.0 ST Array. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

176 Samples

Download data: CEL, TXT

(Submitter supplied) Cisplatin, a platinating agent commonly used in treating several cancers is associated with nephrotoxicity, neurotoxicity and ototoxicity that have hindered its utility. To gain a better understanding of the genetic variants associated with cisplatin induced toxicity, we present a step-wise approach integrating genotypes, gene expression and sensitivity of HapMap cell lines to cisplatin. Cell lines derived from 30 trios of European descent (CEU) and 30 trios of African descent (YRI) were utilized to develop a preclinical model to identify genetic variants and gene expression that contribute to cisplatin induced cytotoxicity in two different populations. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

176 Samples

Download data: CEL, TXT

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 Oct 11, 2012: annotation table updated with netaffx build 32 Protocol: See manufacturer's web site

Organism:

Homo sapiens

453 Series

35 Related Platforms

19794 Samples

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