GEO DataSets

(Submitter supplied) Multiple myeloma (MM) evolves from highly prevalent premalignant condition termed Monoclonal Gammopathy of Undetermined Significance (MGUS). We report an MGUS-MM phenotype arising in transgenic mice with Emu-directed expression of the unfolded protein/ER stress response and plasma cell development spliced isoform factor XBP-1s. Emu-XBP-1s elicited elevated serum Ig and IL-6 levels, skin alterations and with advancing age, a significant proportion of Emu-xbp-1s transgenic mice develop features diagnostic of human MM including bone lytic lesions. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2640

Platform:

GPL1261

16 Samples

Download data: CEL

Analysis of multiple myeloma (MM) tumors and splenic B cells from transgenics overexpressing XBP-1s. XBP-1s is a spliced isoform of XBP-1, a factor that governs unfolded protein/ER stress response and plasma-cell development. Results provide insight into the role of XBP-1 in MM pathogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 specimen, 2 strain sets

Platform:

GPL1261

Series:

GSE6980

16 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...

Organism:

Mus musculus

601 DataSets

4546 Series

40 Related Platforms

58941 Samples

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