GSM1561370[Accession] - GEO DataSets

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Items: 3

Select item 2000639631.

Validation of EZH2 targets in GSCs treated with shNT (control), shMELK, shFOXM1, and EZH2 overexpression

(Submitter supplied) We demonstrate that the catalytic subunit of Polycomb Repressive Complex 2, EZH2, is targeted by the MELK-FOXM1 complex, which in turn promotes resistance to radiation in GSCs. Clinically, EZH2 and MELK are co-expressed in GBM and significantly induced in post-irradiation recurrent tumors whose expression inversely correlated with patient prognosis. Through gain-and loss-of-function study, our data show that MELK or FOXM1 contributes on GSC radioresistance by regulation of EZH2. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17586
5 Samples

Download data: CEL

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Accession:: GSE63963

ID:: 200063963

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000175862.

[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]

(Submitter supplied) #%create_date=Wed Jan 22 15:39:59 2014 PST #%chip_type=HTA-2_0 #%lib_set_name=HTA-2_0 #%lib_set_version=r1 #%genome-species=Homo sapiens #%genome-version=hg19 #%genome-version-ucsc=hg19 #%genome-version-ncbi=GRCh37 #%genome-version-create_date=2009-02-00 #%genome-lifted-method=psl-map.pl #%genome-lifted_from-species=Homo sapiens #%genome-lifted_from-version-ucsc=hg19 #%genome-lifted_from-version-ncbi=GRCh37 #%netaffx-annotation-date=2013-10-15 #%netaffx-annotation-netaffx-build=34 Protocol: See manufacturers website