GEO DataSets

(Submitter supplied) Glucocorticoids regulate diverse physiologic processes and synthetic derivatives of these natural hormones are widely used in the treatment of inflammatory diseases. However, chronic administration often triggers insensitivity and serious side effects including osteoporosis. The underlying mechanisms regulating these side effects are not completely understood. We report here that human osteosarcoma U-2 OS bone cells lacking the glucocorticoid receptor (GR) are resistant to glucocorticoid killing whereas the expression of wild-type GR activates an apoptotic program. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3432

Platform:

GPL1708

60 Samples

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Analysis of glucocorticoid receptor alpha (hGRalpha) isoform -A, -B, -C, or -D expressing osteosarcoma cells for up to 24 h after hGRalpha activation with dexomethasone. Cell apoptosis occurred in a GR isoform-selective manner. Results provide insight into the function of each isoform.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 5 agent, 4 time sets

Platform:

GPL1708

Series:

GSE6711

60 Samples

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(Submitter supplied) This single 44K formatted microarray represents a compiled view of the human genome as it is understood today. The sequence information used to design this product was derived from a broad survey of well known sources such as RefSeq, Goldenpath, Ensembl, Unigene and others. The resulting view of the human genome covers 41K unique genes and transcripts which have been verified and optimized by alignment to the human genome assembly and by Agilent's Empirical Validation process. more...

Organism:

Homo sapiens

6 DataSets

136 Series

1 Related Platform

3292 Samples

Download data: TXT