GSM1493478[Accession] - GEO DataSets

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Items: 4

Select item 2000609101.

Concurrent whole-genome haplotyping and copy number profiling of single cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array; SNP genotyping by SNP array

Platforms:: GPL3718 GPL13829
182 Samples

Download data: CEL

Series

Accession:: GSE60910

ID:: 200060910

PubMed Full text in PMC Similar studies

Select item 2000609092.

Concurrent whole-genome haplotyping and copy number profiling of single cells (Illumina)

(Submitter supplied) Methods for haplotyping and DNA copy number typing of single cells are paramount for studying genomic heterogeneity and enabling genetic diagnosis. Before analyzing the DNA of a single cell by microarray or next-generation sequencing, a whole-genome amplification (WGA) process is required that substantially distorts the frequency and composition of the cell’s alleles. As a consequence, haplotyping methods suffer from error-prone discrete SNP-genotypes (AA, AB, BB), and DNA copy number profiling remains difficult as true DNA copy number aberrations have to be discriminated from WGA-artifacts. more...